⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL140785 | 1.00 | — | — | |
| SCHEMBL1732697 | 1.00 | — | — | |
| SCHEMBL27970244 | 0.98 | LCK (0.79) | — | |
| Ammonia Solution, Strong SCHEMBL27970210 | 0.98 | LCK (0.79) | — | |
| SCHEMBL28064150 | 0.98 | LCK (0.79) | — | |
| Hydrochloric Acid SCHEMBL27855498 | 0.98 | LCK (0.79) | — | |
| Ethane SCHEMBL10653789 | 0.98 | LCK (0.79) | — | |
| SCHEMBL5915022 | 0.98 | LCK (0.79) | — | |
| Bromide SCHEMBL20957492 | 0.98 | LCK (0.79) | — | |
| SCHEMBL28335819 | 0.98 | LCK (0.79) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338621-B2 | Process for the preparation of 2-oxo-1-pyrrolidine derivatives | UCB S.A. (BE) | 2012-12-25 | — | — | US | disclosed |
| US-8168654-B2 | Quinuclidine derivatives binding to mucarinic M3 receptors | NOVARTIS AG (CH) | 2012-05-01 | — | — | US | disclosed |
| EP-1852433-B1 | CARBAZOLE DERIVATIVE, SOLVATE THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ZERIA PHARM CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |
| EP-1806339-B1 | Process for the preparation of 2-oxo-1-pyrrolidine derivatives | UCB PHARMA SA (BE) | 2011-08-17 | — | — | EP | disclosed |
| US-7910597-B2 | platelet lowering agent anagrelide especially 3-and 5-substituted analogues, with reduced potential for cardiovascular side-effects; imidazo[2,1-b]quinazolin-2-one derivatives; by inhibiting megakaryocytopoeisis; antiproliferative agents | SHIRE LLC (US) | 2011-03-22 | — | — | US | disclosed |
| US-20100137343-A1 | SUBSTITUTED QUINAZOLINES | SHIRE LLC (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100041887-A1 | QUINUCLIDINE DERIVATIVES BINDING TO MUCARINIC M3 RECEPTORS | COLLINGWOOD STEPHEN PAUL | 2010-02-18 | — | — | US | disclosed |
| EP-1213288-B1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1213288-B1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20080176877-A1 | SUBSTITUTED QUINAZOLINES | SHIRE LLC (US) | 2008-07-24 | — | — | US | disclosed |
| EP-0445206-B1 | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS | BRITISH BIO TECHNOLOGY (GB) | 1994-03-16 | — | — | EP | disclosed |
| US-5244910-A | Treating hypertension, congestive heart failure | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| US-5240958-A | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-08-31 | — | — | US | disclosed |
| EP-0543936-A4 | RENIN INHIBITORS | — | 1993-06-30 | — | — | EP | disclosed |
| EP-0543936-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003429-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |
| EP-0446267-A1 | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS. | BRITISH BIO TECHNOLOGY (GB) | 1991-09-18 | — | — | EP | disclosed |
| EP-0445206-A1 | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS. | BRITISH BIO TECHNOLOGY (GB) | 1991-09-11 | — | — | EP | disclosed |
| WO-1990005719-A1 | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-05-31 | — | — | WO | disclosed |
| WO-1990005716-A1 | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-05-31 | — | — | WO | disclosed |