Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2305891 | 0.89 | SLC6A2 (0.47) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2302614 | 0.76 | SLC6A4 (0.62) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2302754 | 0.74 | HTR2A (0.47) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2303132 | 0.74 | HTR2A (0.47) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2305362 | 0.74 | HTR2A (0.47) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2305393 | 0.74 | HTR2A (0.47) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2071079 | 0.73 | SLC6A4 (0.63) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2303646 | 0.73 | SLC6A2 (0.57) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2301539 | 0.71 | HTR2A (0.49) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2300412 | 0.71 | HTR2A (0.49) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062996-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |