Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2305030 | 0.89 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL12426665 | 0.88 | SLC6A4 (0.63) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL2307054 | 0.88 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL2302913 | 0.85 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL2303403 | 0.84 | SLC6A2 (0.58) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL2301868 | 0.84 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL3108485 | 0.83 | SLC6A4 (0.70) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL2304229 | 0.82 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL2301449 | 0.81 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL2300195 | 0.81 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062996-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |