SCHEMBL14498271

SCHEMBL14498271

CCC(NC(=O)c1ccccc1NS(=O)(=O)c1cccc2cccnc12)c1ccc(C)nc1

nearest known ligand 0.82

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 8/20 0.82
MEN1 O00255 3/20 0.57
KMT2A Q03164 3/20 0.57
ALDH1A1 P00352 2/20 0.53
MAPT P10636 1/20 0.53
HPGD P15428 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
KCNK3 O14649 2/20 0.51
SLC40A1 Q9NP59 4/20 0.50
KCNK9 Q9NPC2 1/20 0.50
GAA P10253 1/20 0.50
POLB P06746 1/20 0.48
MMP2 P08253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14498256 0.91 KCNA5 (0.88) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL5072756 0.90 KCNA5 (0.86) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL5615965 0.90 KCNA5 (1.00) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL5074801 0.90 KCNA5 (1.00) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL5072331 0.90 KCNA5 (1.00) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL14498283 0.90 KCNA5 (0.77) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL5072332 0.89 KCNA5 (0.86) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL5072724 0.89 KCNA5 (0.86) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL5072319 0.84 KCNA5 (0.76) KCNA5MEN1KMT2AALDH1A1MAPT
SCHEMBL14301357 0.84 KCNA5 (0.78) KCNA5MEN1KMT2AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7235664-B2 Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-06-26 US disclosed
US-7235664-B2 Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-06-26 US disclosed