Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763552 | 0.82 | HTT (0.61) | HTTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL14523844 | 0.80 | KDM4E (0.47) | HTTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL16693907 | 0.79 | HTT (0.45) | HTTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL7324216 | 0.78 | CYP1A2 (0.57) | HTTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL6988391 | 0.77 | HTT (0.49) | HTTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL14498557 | 0.77 | TSHR (0.41) | HTTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL1699275 | 0.76 | HPGD (0.49) | HTTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL1253988 | 0.74 | CYP1A2 (0.46) | HTTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL14498556 | 0.73 | POLB (0.37) | HTTALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL1255046 | 0.73 | GLA (0.58) | ALDH1A1HPGDHSD17B10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |