Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.61 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1488560 | 0.93 | MAP2K1 (0.60) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL29413590 | 0.93 | MAP2K1 (0.60) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3975218 | 0.90 | MAP2K1 (0.51) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL14500091 | 0.90 | MAP2K1 (0.53) | MAP2K1MAP2K2DGAT1IRAK4 | |
| SCHEMBL14499784 | 0.90 | MAP2K1 (0.51) | MAP2K1MAP2K2ABCB11NQO2IRAK4 | |
| SCHEMBL15088109 | 0.90 | MAP2K1 (0.48) | MAP2K1MAP2K2IRAK4 | |
| SCHEMBL14499761 | 0.89 | MAP2K1 (0.61) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3975584 | 0.85 | MAP2K1 (0.67) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL15088122 | 0.83 | MAP2K1 (0.58) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3980231 | 0.83 | MAP2K1 (0.56) | MAP2K1MAP2K2ABCB11NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230099-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA, INC. (US) | 2007-06-12 | — | — | US | disclosed |