Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | SMC2 | O95347 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.41 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499794 | 1.00 | MAP2K1 (0.42) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL14499762 | 0.93 | MAP2K1 (0.50) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14499760 | 0.93 | MAP2K1 (0.50) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14500089 | 0.92 | MAP2K1 (0.51) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL14499763 | 0.89 | MAP2K1 (0.48) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL15088175 | 0.88 | MAP2K1 (0.56) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL15088118 | 0.87 | MAP2K1 (0.49) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL14499785 | 0.86 | MAP2K1 (0.49) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL13843669 | 0.86 | MAP2K1 (0.49) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14500051 | 0.86 | MAP2K1 (0.43) | MAP2K1MAP2K2CSNK2A2SMC2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673339-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2013-07-03 | — | — | EP | disclosed |
| US-7230099-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA, INC. (US) | 2007-06-12 | — | — | US | disclosed |