Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.63 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.63 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.63 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 4/20 | 0.50 |
| ▸ | CCNK | O75909 | 2/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 7/20 | 0.48 |
| ▸ | JAK1 | P23458 | 6/20 | 0.48 |
| ▸ | JAK3 | P52333 | 4/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14500070 | 1.00 | AURKB (0.63) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL29541199 | 1.00 | AURKB (0.63) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL101331 | 1.00 | AURKB (0.63) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL15412453 | 0.98 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| Nitrous Acid SCHEMBL100612 | 0.93 | AURKA (0.56) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL100267 | 0.91 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL100113 | 0.91 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL99168 | 0.91 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL100745 | 0.89 | AURKB (0.64) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL29541047 | 0.89 | AURKB (0.64) | AURKBAURKAINCENPTPX2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135461-A1 | 3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; immune-related diseases, skin disorders, myeloid proliferative disorders, cancer | INCYTE CORPORATION | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135461-A1 | 3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; immune-related diseases, skin disorders, myeloid proliferative disorders, cancer | JAK1, JAK3, MAP3K4 | AURKB 613/4885AURKA 594/4885INCENP 4326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.