Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HTR1B | P28222 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.57 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12530444 | 0.90 | MCHR1 (0.76) | MCHR1MAPTRAB9ANPC1LMNA | |
| SCHEMBL12530925 | 0.89 | MCHR1 (0.69) | MCHR1MAPTRAB9AATMNPC1 | |
| SCHEMBL12530893 | 0.88 | MCHR1 (0.78) | MCHR1MAPTRAB9ANPC1TP53 | |
| SCHEMBL12529830 | 0.88 | MCHR1 (0.89) | MCHR1RAB9ANPC1 | |
| SCHEMBL12529621 | 0.88 | MCHR1 (0.89) | MCHR1MAPTRAB9ANPC1TP53 | |
| SCHEMBL1750361 | 0.88 | MCHR1 (0.81) | MCHR1 | |
| SCHEMBL1750252 | 0.88 | MCHR1 (0.78) | MCHR1MAPTRAB9ANPC1LMNA | |
| SCHEMBL1750121 | 0.87 | MCHR1 (0.76) | MCHR1 | |
| SCHEMBL12530860 | 0.87 | MCHR1 (0.76) | MCHR1RAB9ANPC1TP53MAPK1 | |
| SCHEMBL1749572 | 0.87 | MCHR1 (0.76) | MCHR1PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223788-B2 | therapy for eating disorders, anorexigenic agents, antidiabetic agents, reducing weight in mammals, circadian rhythm disease, psychological disorders | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |
| US-7223788-B2 | therapy for eating disorders, anorexigenic agents, antidiabetic agents, reducing weight in mammals, circadian rhythm disease, psychological disorders | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |