Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5364860 | 1.00 | PPARA (0.50) | PPARAPPARGKDM4EMEN1KMT2A | |
| SCHEMBL5357732 | 0.91 | PPARA (0.48) | PPARAPPARGKDM4EMEN1KMT2A | |
| SCHEMBL5358190 | 0.91 | PPARA (0.52) | PPARAPPARGKDM4EMEN1KMT2A | |
| SCHEMBL6658219 | 0.83 | PPARA (0.54) | PPARAPPARGKDM4EMEN1KMT2A | |
| SCHEMBL5361848 | 0.82 | PPARG (0.57) | PPARAPPARGKDM4EKMT2APPARD | |
| SCHEMBL6658216 | 0.82 | PPARA (0.51) | PPARAPPARGKDM4EMEN1KMT2A | |
| SCHEMBL5364805 | 0.81 | PPARG (0.51) | PPARAPPARGKDM4EKMT2APPARD | |
| SCHEMBL5360529 | 0.81 | KMT2A (0.50) | PPARAPPARGKDM4EMEN1KMT2A | |
| SCHEMBL5364230 | 0.80 | PPARA (0.43) | PPARAPPARGKDM4EKMT2ACNR1 | |
| SCHEMBL11571249 | 0.79 | KDM4E (0.53) | PPARAPPARGKDM4EPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220880-B2 | Amide linker peroxisome proliferator activated receptor modulators | ELI LILLY AND COMPANY (US) | 2007-05-22 | — | — | US | disclosed |