Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 13/20 | 0.50 |
| ▸ | ESR1 | P03372 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 10/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6419166 | 0.89 | PPARA (0.54) | PPARAESR1ESR2PPARGPPARD | |
| SCHEMBL977513 | 0.89 | PPARA (0.54) | PPARAESR1ESR2PPARGPPARD | |
| SCHEMBL977514 | 0.89 | PPARA (0.54) | PPARAESR1ESR2PPARGPPARD | |
| SCHEMBL5379702 | 0.88 | ESR1 (0.45) | PPARAESR1TSHRALDH1A1CHRM1 | |
| SCHEMBL5379694 | 0.88 | ESR1 (0.45) | PPARAESR1TSHRALDH1A1CHRM1 | |
| SCHEMBL3535230 | 0.84 | ESR1 (0.58) | PPARAESR1TSHRESR2PPARG | |
| SCHEMBL3535227 | 0.84 | ESR1 (0.58) | PPARAESR1TSHRESR2PPARG | |
| SCHEMBL14532664 | 0.84 | PPARA (0.60) | PPARAPPARGPPARDLMNA | |
| SCHEMBL7637724 | 0.84 | ESR1 (0.56) | PPARAESR1TSHRALDH1A1CHRM1 | |
| SCHEMBL5104386 | 0.82 | ESR1 (0.51) | PPARAESR1TSHRALDH1A1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220880-B2 | Amide linker peroxisome proliferator activated receptor modulators | ELI LILLY AND COMPANY (US) | 2007-05-22 | — | — | US | disclosed |
| US-7220880-B2 | Amide linker peroxisome proliferator activated receptor modulators | ELI LILLY AND COMPANY (US) | 2007-05-22 | — | — | US | disclosed |