Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12404395 | 0.81 | AURKA (0.63) | AURKAAURKBFYNTTKPTK6 | |
| SCHEMBL8241671 | 0.80 | AURKA (0.55) | AURKAAURKBFYNTTKPTK6 | |
| SCHEMBL8247273 | 0.80 | AURKA (0.69) | AURKAAURKBFYNTTKMAPKAPK5 | |
| SCHEMBL8240979 | 0.79 | AURKA (0.58) | AURKAAURKBFYNTTKPTK6 | |
| SCHEMBL8239882 | 0.79 | AURKA (0.63) | AURKAAURKBFYNTTKPTK6 | |
| SCHEMBL8249789 | 0.79 | AURKA (0.58) | AURKAAURKBTTK | |
| SCHEMBL8239703 | 0.77 | AURKA (0.56) | AURKAAURKBFYNTTKPTK6 | |
| SCHEMBL8240283 | 0.77 | AURKA (0.66) | AURKAAURKBTTKPTK6FLT3 | |
| SCHEMBL8247128 | 0.77 | AURKA (0.63) | AURKAAURKBFYNTTKPTK6 | |
| SCHEMBL8240369 | 0.77 | AURKA (0.60) | AURKAAURKBFYNTTKPTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105864-A1 | Methods for inhibiting protein kinases | SCHERING CORPORATION | 2007-05-10 | — | — | US | disclosed |
| US-20070105864-A1 | Methods for inhibiting protein kinases | SCHERING CORPORATION | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105864-A1 | Methods for inhibiting protein kinases | PIM1, PIM2, PIM3 | AURKA 5/4885AURKB 24/4885FYN 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.