Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.52 |
| ▸ | CCND1 | P24385 | 12/20 | 0.52 |
| ▸ | CDK11A | Q9UQ88 | 11/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.51 |
| ▸ | CDK9 | P50750 | 10/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.46 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338443 | 0.90 | CDK4 (0.56) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4338779 | 0.87 | GSK3A (0.65) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4333416 | 0.86 | CDK4 (0.61) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4333581 | 0.86 | CDK4 (0.58) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4331507 | 0.85 | CDK4 (0.51) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4336041 | 0.84 | CDK4 (0.56) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4337167 | 0.83 | CDK4 (0.62) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4336279 | 0.83 | CDK4 (0.62) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL13785057 | 0.83 | CDK4 (0.61) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4338041 | 0.83 | CDK4 (0.61) | CDK4CCND1CDK11ACCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211576-B2 | Diaminothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-7211576-B2 | Diaminothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | disclosed |