Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.59 |
| ▸ | CCND1 | P24385 | 9/20 | 0.59 |
| ▸ | CDK11A | Q9UQ88 | 8/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.59 |
| ▸ | CDK9 | P50750 | 7/20 | 0.59 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.58 |
| ▸ | CDK2 | P24941 | 5/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.55 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.54 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13785096 | 0.93 | CDK4 (0.57) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4333446 | 0.92 | CCNA2 (0.59) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4340809 | 0.91 | CCNA2 (0.63) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL14508291 | 0.91 | CDK4 (0.60) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4337579 | 0.91 | CCNA2 (0.60) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL13785004 | 0.91 | CDK4 (0.55) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL13785100 | 0.90 | CDK4 (0.61) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4333315 | 0.90 | CCNA2 (0.64) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4338676 | 0.90 | CDK4 (0.72) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4338839 | 0.90 | CDK4 (0.57) | CDK4CCND1CDK11ACCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211576-B2 | Diaminothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-7211576-B2 | Diaminothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | disclosed |