Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.64 |
| ▸ | CXCR1 | P25024 | 12/20 | 0.64 |
| ▸ | CCR7 | P32248 | 1/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12086708 | 0.82 | CXCR2 (0.79) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL14511352 | 0.81 | CXCR2 (0.52) | CXCR2CXCR1CCR6 | |
| SCHEMBL14511107 | 0.80 | CXCR2 (0.56) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12087092 | 0.78 | CXCR2 (0.74) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL13208150 | 0.78 | CXCR2 (1.00) | CXCR2CXCR1CCR7 | |
| SCHEMBL13207028 | 0.77 | CXCR2 (0.75) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL13406984 | 0.77 | CXCR2 (0.67) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL14450755 | 0.77 | CXCR2 (0.54) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL14511220 | 0.76 | CXCR2 (0.72) | CXCR2CXCR1 | |
| SCHEMBL13479554 | 0.75 | CXCR2 (0.69) | CXCR2CXCR1CCR7CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381590-B1 | 3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2007-06-20 | — | — | EP | disclosed |