Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 4/20 | 0.60 |
| ▸ | CDK1 | P06493 | 4/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.60 |
| ▸ | CCR6 | P51684 | 1/20 | 0.60 |
| ▸ | TGM2 | P21980 | 2/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618358 | 1.00 | CCNB2 (0.60) | CCNB2CDK1CCNB1CCNB3HSP90AA1 | |
| SCHEMBL5618363 | 1.00 | CCNB2 (0.60) | CCNB2CDK1CCNB1CCNB3HSP90AA1 | |
| SCHEMBL5619602 | 0.83 | IDO1 (0.50) | CCNB2CDK1CCNB1CCNB3TGM2 | |
| SCHEMBL5619605 | 0.83 | IDO1 (0.50) | CCNB2CDK1CCNB1CCNB3TGM2 | |
| SCHEMBL14515139 | 0.83 | IDO1 (0.50) | CCNB2CDK1CCNB1CCNB3TGM2 | |
| SCHEMBL2826129 | 0.83 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3HSP90AA1 | |
| SCHEMBL2826131 | 0.83 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3HSP90AA1 | |
| SCHEMBL13207326 | 0.83 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3HSP90AA1 | |
| SCHEMBL25688462 | 0.83 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3HSP90AA1 | |
| SCHEMBL25684464 | 0.77 | CCNB2 (0.50) | CCNB2CDK1CCNB1CCNB3HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214700-B2 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | SUGEN INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-7214700-B2 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | SUGEN INC. (US) | 2007-05-08 | — | — | US | disclosed |