Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 14/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420450 | 0.90 | CYP3A4 (0.77) | CYP3A4CYP2D6 | |
| SCHEMBL14515324 | 0.90 | CYP3A4 (0.64) | CYP3A4CYP2D6 | |
| SCHEMBL14515299 | 0.89 | CYP3A4 (0.79) | CYP3A4CYP2D6 | |
| SCHEMBL8419048 | 0.88 | CYP3A4 (0.69) | CYP3A4CYP2D6 | |
| SCHEMBL8417414 | 0.87 | CYP3A4 (0.80) | CYP3A4CYP2D6 | |
| SCHEMBL12205065 | 0.87 | CYP3A4 (0.84) | CYP3A4CYP2D6 | |
| SCHEMBL8229211 | 0.87 | CYP3A4 (0.71) | CYP3A4CYP2D6 | |
| SCHEMBL8229201 | 0.87 | CYP3A4 (1.00) | CYP3A4CYP2D6 | |
| SCHEMBL8422342 | 0.84 | CYP3A4 (0.77) | CYP3A4CYP2D6 | |
| SCHEMBL8229409 | 0.84 | CYP3A4 (0.77) | CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220735-B2 | Benzimidazolone histamine H3 antagonists | SCHERING CORPORATION (US) | 2007-05-22 | — | — | US | disclosed |
| US-7220735-B2 | Benzimidazolone histamine H3 antagonists | SCHERING CORPORATION (US) | 2007-05-22 | — | — | US | disclosed |