Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237099 | 0.87 | KDM4E (0.53) | KDM4EHTTHSD17B10CASP1CASP7 | |
| SCHEMBL8237095 | 0.87 | KDM4E (0.53) | KDM4EHTTHSD17B10CASP1CASP7 | |
| SCHEMBL8277740 | 0.82 | KDM4E (0.62) | KDM4EHTTHSD17B10CASP1CASP7 | |
| SCHEMBL8243458 | 0.77 | KDM4E (0.53) | KDM4EHTTHSD17B10CASP1CASP7 | |
| SCHEMBL13924000 | 0.77 | KDM4E (0.53) | KDM4EHTTHSD17B10CASP1CASP7 | |
| SCHEMBL8243786 | 0.77 | KDM4E (0.50) | KDM4EHTTALDH1A1MAPTTDP1 | |
| SCHEMBL6101444 | 0.70 | KDM4E (0.78) | KDM4EHTTHSD17B10CASP1CASP7 | |
| SCHEMBL6101448 | 0.70 | KDM4E (0.78) | KDM4EHTTHSD17B10CASP1CASP7 | |
| SCHEMBL8243976 | 0.70 | KDM4E (0.78) | KDM4EHTTHSD17B10CASP1CASP7 | |
| SCHEMBL12348405 | 0.68 | KDM4E (0.52) | KDM4EHTTHSD17B10CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070393-A2 | MGLUR1 ANATGONISTS AS THERAPEUTIC AGENTS | SCHERING CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |