Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14198765 | 0.79 | KMT2A (0.58) | KMT2ASMN1; SMN2C5AR1CALCRL | |
| SCHEMBL12362418 | 0.77 | KMT2A (0.57) | KMT2ASMN1; SMN2C5AR1CALCRLDAO | |
| SCHEMBL12362443 | 0.76 | KMT2A (0.54) | KMT2ASMN1; SMN2C5AR1CALCRL | |
| SCHEMBL12362417 | 0.76 | SMN1; SMN2 (0.54) | KMT2ASMN1; SMN2C5AR1CALCRLNPC1 | |
| SCHEMBL12362442 | 0.74 | KMT2A (0.53) | KMT2ASMN1; SMN2C5AR1CALCRLGAA | |
| SCHEMBL14518251 | 0.73 | KMT2A (0.51) | KMT2ASMN1; SMN2C5AR1GAA | |
| SCHEMBL12362445 | 0.73 | KMT2A (0.54) | KMT2ASMN1; SMN2C5AR1CALCRL | |
| SCHEMBL261520 | 0.71 | CALCRL (0.46) | KMT2ASMN1; SMN2C5AR1CALCRL | |
| SCHEMBL14198898 | 0.69 | DAO (0.55) | KMT2ASMN1; SMN2C5AR1CALCRLABCB1 | |
| SCHEMBL14198762 | 0.69 | KMT2A (0.40) | KMT2ASMN1; SMN2C5AR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |