SCHEMBL14520396

SCHEMBL14520396

COc1cccc(C2(CNC(=O)c3ccccc3)CCCN(c3ccccc3OC)CC2)c1

nearest known ligand 0.65

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SOAT1 P35610 8/20 0.65
ALDH1A1 P00352 1/20 0.63
DRD2 P14416 5/20 0.55
DRD4 P21917 5/20 0.55
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.53
DRD3 P35462 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5478376 0.96 SOAT1 (0.69) SOAT1ALDH1A1DRD2DRD4DRD3
SCHEMBL14520395 0.91 SOAT1 (0.59) SOAT1ALDH1A1DRD2DRD4
SCHEMBL5470497 0.88 SOAT1 (0.73) SOAT1
SCHEMBL14520394 0.88 SOAT1 (0.70) SOAT1
SCHEMBL14520397 0.88 SOAT1 (0.65) SOAT1
SCHEMBL14520349 0.87 SOAT1 (0.62) SOAT1ALDH1A1DRD2DRD4
SCHEMBL14520373 0.85 SOAT1 (0.59) SOAT1
SCHEMBL5475890 0.84 SOAT1 (0.70) SOAT1
SCHEMBL14520346 0.83 SOAT1 (0.75) SOAT1
SCHEMBL14520354 0.83 SOAT1 (0.69) SOAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070078120-A1 Novel piperidine derivative DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-04-05 US disclosed
US-20070078120-A1 Novel piperidine derivative DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070078120-A1 Novel piperidine derivative LDLR, PRMT5, MSR1 SOAT1 1040/4885ALDH1A1 2990/4885DRD2 551/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.