Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14521072 | 0.85 | PDPK1 (0.50) | NPC1TGM2PDPK1MDM2AURKA | |
| SCHEMBL14521098 | 0.84 | NPC1 (0.52) | NPC1PDPK1MDM2AURKARAF1 | |
| SCHEMBL14521078 | 0.84 | MDM2 (0.55) | NPC1PDPK1MDM2AURKARAF1 | |
| SCHEMBL14521024 | 0.84 | NPC1 (0.52) | NPC1PDPK1MDM2AURKARAF1 | |
| SCHEMBL14521033 | 0.84 | NPC1 (0.60) | NPC1TGM2PDPK1MDM2AURKA | |
| SCHEMBL14521075 | 0.84 | MDM2 (0.58) | NPC1PDPK1MDM2AURKARAF1 | |
| SCHEMBL14521077 | 0.83 | MDM2 (0.54) | NPC1PDPK1MDM2AURKARAF1 | |
| SCHEMBL14521065 | 0.83 | KMT2A (0.53) | NPC1PDPK1MDM2AURKARAF1 | |
| SCHEMBL14521057 | 0.83 | PDPK1 (0.54) | NPC1PDPK1MDM2AURKARAF1 | |
| SCHEMBL14521059 | 0.82 | NPC1 (0.49) | NPC1PDPK1MDM2AURKARAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070088051-A1 | INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-19 | — | — | US | disclosed |
| US-20070088051-A1 | INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088051-A1 | INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | MKI67, CCNT1, CCNA1 | NPC1 1022/4885TGM2 4589/4885PDPK1 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.