Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4152686 | 0.91 | MAPT (0.51) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL4152684 | 0.91 | MAPT (0.51) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL4147348 | 0.90 | MAPT (0.52) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL4147352 | 0.90 | MAPT (0.52) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL13630666 | 0.89 | MAPT (0.45) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL14521529 | 0.87 | ITK (0.40) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL2427841 | 0.80 | MAPT (0.44) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL4155593 | 0.80 | KDM4E (0.42) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL2427840 | 0.80 | MAPT (0.44) | MAPTKDM4ENPC1CASP3RAB9A | |
| SCHEMBL13852139 | 0.80 | KDM4E (0.42) | MAPTKDM4ENPC1CASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007071434-A1 | ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-28 | — | — | WO | disclosed |