Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 6/20 | 0.66 |
| ▸ | SKP1 | P63208 | 6/20 | 0.66 |
| ▸ | SKP2 | Q13309 | 6/20 | 0.66 |
| ▸ | ADK | P55263 | 1/20 | 0.51 |
| ▸ | PGK1 | P00558 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14523394 | 0.88 | CKS1B (0.67) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL14523364 | 0.87 | CKS1B (0.68) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL14523407 | 0.86 | CKS1B (0.63) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL14523405 | 0.85 | CKS1B (0.71) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL4695725 | 0.85 | CKS1B (0.62) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL14523396 | 0.84 | CKS1B (0.70) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL14523362 | 0.83 | CKS1B (0.58) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL14523409 | 0.83 | CKS1B (0.60) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL5530911 | 0.83 | CKS1B (0.68) | CKS1BSKP1SKP2ADKPGK1 | |
| SCHEMBL5516374 | 0.82 | CKS1B (0.63) | CKS1BSKP1SKP2ADKPGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070078135-A1 | Substituted heteroaryl CB1 antagonists | NEUROGEN CORPORATION (US) | 2007-04-05 | — | — | US | disclosed |
| US-20070078135-A1 | Substituted heteroaryl CB1 antagonists | NEUROGEN CORPORATION (US) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078135-A1 | Substituted heteroaryl CB1 antagonists | CNR1, CNR2, OPRL1 | CKS1B 1836/4885SKP1 3576/4885SKP2 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.