SCHEMBL14524985

SCHEMBL14524985

O=C(NC1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C[C@H]1NC(=O)c1ccc(Cl)s1)c1ccc(-n2ccccc2=O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 1.00
F2 P00734 4/20 0.80
F11 P03951 3/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4786369 1.00 F10 (1.00) F10F2F11
SCHEMBL14524991 0.89 F10 (1.00) F10F2F11
SCHEMBL5429166 0.89 F10 (1.00) F10F2F11
SCHEMBL5435246 0.87 F10 (1.00) F10F2F11
SCHEMBL5441211 0.86 F10 (1.00) F10F2F11
SCHEMBL5430209 0.86 F10 (0.84) F10F2F11
SCHEMBL5430203 0.86 F10 (0.84) F10F2F11
SCHEMBL5431971 0.84 F10 (0.86) F10F2F11
SCHEMBL14490781 0.83 F10 (1.00) F10F2F11
SCHEMBL14524990 0.83 F10 (1.00) F10F2F11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7205318-B2 Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2007-04-17 US disclosed