SCHEMBL14525751

SCHEMBL14525751

CCCc1ccc(-c2ccc(C3CCc4c(ccc(Cl)c4F)C3)cc2)c(F)c1

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHKA P35790 1/20 0.34
MPL P40238 1/20 0.33
CYP3A4 P08684 3/20 0.32
CYP2C9 P11712 2/20 0.32
APP P05067 2/20 0.32
CYP11B1 P15538 3/20 0.32
CYP11B2 P19099 3/20 0.32
RARB P10826 1/20 0.31
GPR119 Q8TDV5 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31
DRD3 P35462 3/20 0.30
DRD2 P14416 2/20 0.30
NR1H4 Q96RI1 1/20 0.30
HTR1A P08908 1/20 0.30
HTR7 P34969 1/20 0.30
HTR2A P28223 1/20 0.30
GRM2 Q14416 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6158197 0.75 SPHK1 (0.35) DRD3DRD2
SCHEMBL10945841 0.74 CYP2C9 (0.44) CHKACYP3A4CYP2C9APPRARB
SCHEMBL10945851 0.74 CYP2C9 (0.44) CHKACYP3A4CYP2C9APPRARB
SCHEMBL8447403 0.73 CYP2C9 (0.35) CYP3A4CYP2C9APPCYP11B1CYP11B2
SCHEMBL8447406 0.73 CYP2C9 (0.35) CYP3A4CYP2C9APPCYP11B1CYP11B2
SCHEMBL8451523 0.73 CYP2C9 (0.38) CHKACYP3A4CYP2C9APPRARB
SCHEMBL8451524 0.73 CYP2C9 (0.38) CHKACYP3A4CYP2C9APPRARB
SCHEMBL9853707 0.73 CYP2C9 (0.43) CHKACYP3A4CYP2C9APPRARB
SCHEMBL9853709 0.73 CYP2C9 (0.43) CHKACYP3A4CYP2C9APPRARB
SCHEMBL14228674 0.72 SPHK1 (0.33) DRD3DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7198827-B1 Nematic liquid crystal composition and liquid crystal display device using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 2007-04-03 US disclosed
US-7198827-B1 Nematic liquid crystal composition and liquid crystal display device using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 2007-04-03 US disclosed