SCHEMBL14526652

SCHEMBL14526652

O=C(O[C@@H]1CCNC1)C(O)(c1ccccc1)C1CCCC1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 5/20 0.61
CHRM2 P08172 3/20 0.61
ALDH1A1 P00352 2/20 0.60
CHRM1 P11229 2/20 0.60
KCNH2 Q12809 2/20 0.60
CYP1A2 P05177 2/20 0.60
CHRM4 P08173 1/20 0.60
CHRM5 P08912 1/20 0.60
HRH1 P35367 1/20 0.60
HTR2B P41595 1/20 0.60
CYP3A4 P08684 2/20 0.59
CYP2D6 P10635 2/20 0.59
KEAP1 Q14145 1/20 0.55
NFE2L2 Q16236 1/20 0.55
POLB P06746 1/20 0.48
SLC6A3 Q01959 1/20 0.46
HTT P42858 1/20 0.46
CYP2C9 P11712 1/20 0.45
PKM P14618 1/20 0.45
NFKB1 P19838 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1999952 1.00 CHRM3 (0.61) CHRM3CHRM2ALDH1A1CHRM1KCNH2
SCHEMBL11465571 0.99 CHRM3 (0.60) CHRM3CHRM2ALDH1A1CHRM1KCNH2
SCHEMBL20476344 0.92 CHRM3 (0.64) CHRM3CHRM2ALDH1A1CHRM1KCNH2
Hydrochloric Acid SCHEMBL6588205 0.88 CHRM3 (0.59) CHRM3CHRM2ALDH1A1CHRM1KCNH2
SCHEMBL14753777 0.84 CYP3A4 (0.70) CHRM3CHRM2ALDH1A1CHRM1KCNH2
SCHEMBL14753782 0.84 CYP3A4 (0.70) CHRM3CHRM2ALDH1A1CHRM1KCNH2
SCHEMBL2128059 0.84 CHRM3 (0.65) CHRM3CHRM2ALDH1A1CHRM1KCNH2
SCHEMBL6402188 0.83 CHRM2 (0.61) CHRM3CHRM2CHRM1
SCHEMBL6402190 0.83 CHRM2 (0.61) CHRM3CHRM2CHRM1
SCHEMBL6404431 0.83 CHRM2 (0.61) CHRM3CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007058971-A2 SOFT ANTICHOLINERGIC ESTERS BODOR NICHOLAS S (US) 2007-05-24 WO disclosed
WO-2007059021-A1 SOFT ANTICHOLINERGIC ZWITTERIONS BODOR NICHOLAS S (US) 2007-05-24 WO disclosed