Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 7/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14527300 | 0.92 | KDR (0.54) | KDRRETBRAFMEN1KMT2A | |
| SCHEMBL14527328 | 0.88 | KDR (0.56) | KDRRETBRAFRAF1MAPK14 | |
| SCHEMBL14527324 | 0.85 | KDR (0.52) | KDRRETBRAFNR1H2NR1H3 | |
| SCHEMBL14527390 | 0.85 | KMT2A (0.54) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL14527336 | 0.85 | NPC1 (0.58) | KDRRETBRAFMAPK14PLK4 | |
| SCHEMBL6014190 | 0.84 | KDR (0.59) | KDRRETBRAFMEN1KMT2A | |
| SCHEMBL14527430 | 0.84 | RET (0.69) | KDRRETBRAFMEN1KMT2A | |
| SCHEMBL14527327 | 0.84 | KDR (0.56) | KDRRETBRAFRAF1MAPK14 | |
| SCHEMBL14527335 | 0.84 | BRAF (0.58) | KDRRETBRAFRAF1MET | |
| SCHEMBL14527329 | 0.84 | KDR (0.56) | KDRRETBRAFRAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093529-A1 | Diacylhydrazine derivatives | MERCK PATENT GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
| US-20070093529-A1 | Diacylhydrazine derivatives | MERCK PATENT GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093529-A1 | Diacylhydrazine derivatives | BRAF, RAF1, NRAS | KDR 1543/4885RET 77/4885BRAF 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.