Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.59 |
| ▸ | CDK2 | P24941 | 9/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784405 | 0.86 | GSK3B (0.61) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL13893796 | 0.86 | GSK3B (0.61) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL13998466 | 0.86 | CDK2 (0.69) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL13309220 | 0.85 | GSK3B (0.47) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL11931061 | 0.84 | GSK3B (0.62) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL11931057 | 0.84 | GSK3B (0.61) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL14516133 | 0.84 | GSK3B (0.56) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL13885049 | 0.84 | GSK3B (0.75) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL13885070 | 0.83 | GSK3B (0.60) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL11931062 | 0.82 | GSK3B (0.61) | GSK3BCDK2CHEK1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534712-B1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-05-16 | — | — | EP | disclosed |