Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931068 | 0.89 | GSK3B (0.54) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL14529037 | 0.85 | KDM4E (0.44) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL13309179 | 0.85 | GSK3B (0.48) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL13309463 | 0.84 | GSK3B (0.51) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL14528807 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL13309469 | 0.84 | GSK3B (0.50) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL13309318 | 0.84 | GSK3B (0.50) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL13309102 | 0.83 | CA12 (0.45) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL13309054 | 0.82 | GSK3B (0.54) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL13309060 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1MAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534712-B1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-05-16 | — | — | EP | disclosed |