Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 7/20 | 0.54 |
| ▸ | FES | P07332 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | FRK | P42685 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428808 | 0.92 | PIKFYVE (0.65) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL428807 | 0.92 | PIKFYVE (0.65) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL18115383 | 0.83 | PIKFYVE (0.72) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL18115378 | 0.83 | PIKFYVE (0.72) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL13758994 | 0.80 | FES (0.48) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL16822434 | 0.79 | PIKFYVE (0.65) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL16822435 | 0.79 | PIKFYVE (0.65) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL427727 | 0.79 | PIKFYVE (0.49) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL427728 | 0.79 | PIKFYVE (0.49) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL424837 | 0.78 | TYK2 (0.84) | PIKFYVEFESFERTYK2FRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050980-A2 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2007-05-03 | — | — | WO | disclosed |