Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 7/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 7/20 | 0.34 |
| ▸ | LCK | P06239 | 6/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14529984 | 0.86 | CHEK1 (0.44) | AURKBPTK6CHEK1AURKACDK2 | |
| SCHEMBL8241447 | 0.86 | CHEK1 (0.44) | AURKBPTK6CHEK1AURKACDK2 | |
| SCHEMBL14538359 | 0.81 | CHEK1 (0.46) | AURKBPTK6LCKCHEK1AURKA | |
| SCHEMBL14530731 | 0.78 | AURKA (0.38) | AURKBPTK6LCKAURKASYK | |
| SCHEMBL14507767 | 0.78 | CHEK1 (0.47) | AURKBPTK6CHEK1AURKACDK2 | |
| SCHEMBL14530381 | 0.77 | AURKA (0.56) | AURKBLCKCHEK1AURKACDK2 | |
| SCHEMBL8248254 | 0.77 | AURKB (0.53) | AURKBPTK6LCKCHEK1AURKA | |
| SCHEMBL14536854 | 0.73 | CHEK1 (0.42) | AURKBPTK6LCKCHEK1AURKA | |
| SCHEMBL8241422 | 0.69 | CHEK1 (0.61) | AURKBPTK6LCKCHEK1AURKA | |
| SCHEMBL8246925 | 0.68 | CHEK1 (0.46) | AURKBPTK6LCKCHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |