Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.69 |
| ▸ | CDC25B | P30305 | 1/20 | 0.69 |
| ▸ | CDC25C | P30307 | 1/20 | 0.69 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 8/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | AR | P10275 | 3/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19195913 | 0.91 | CDC25A (0.59) | CDC25ACDC25BCDC25CDUSP3KDM4E | |
| SCHEMBL26124942 | 0.89 | MAPT (0.68) | CDC25ACDC25BCDC25CDUSP3KDM4E | |
| SCHEMBL4267715 | 0.87 | KDM4E (0.68) | CDC25ACDC25BCDC25CDUSP3KDM4E | |
| SCHEMBL11215130 | 0.85 | SREBF2 (0.82) | KDM4ESMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL11212983 | 0.85 | SREBF2 (0.82) | KDM4ESMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL11213828 | 0.85 | SREBF2 (0.82) | KDM4ESMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL4279335 | 0.85 | MAPT (0.74) | CDC25ACDC25BCDC25CDUSP3KDM4E | |
| SCHEMBL12171396 | 0.84 | CSNK2A1 (0.65) | CDC25ACDC25BCDC25CDUSP3KDM4E | |
| SCHEMBL11464717 | 0.83 | SREBF2 (0.79) | KDM4ESMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL2781370 | 0.83 | KDM4E (0.85) | KDM4ESMN1; SMN2MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656953-B2 | Inhibition of cell proliferation | UNIVERSITY OF SOUTH FLORIDA (US) | 2017-05-23 | — | — | US | disclosed |
| US-20140221658-A1 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-08-07 | — | — | US | disclosed |
| US-8642278-B2 | Inhibition of cell proliferation | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-02-04 | — | — | US | disclosed |
| WO-2007062222-A2 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221658-A1 | INHIBITION OF CELL PROLIFERATION | RB1, RAF1, NRAS | CDC25A 103/4885CDC25B 267/4885CDC25C 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.