Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 11/20 | 0.42 |
| ▸ | AURKA | O14965 | 10/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | STK25 | O00506 | 1/20 | 0.42 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | MUSK | O15146 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14531907 | 0.95 | AURKB (0.42) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL14531902 | 0.92 | AURKB (0.49) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL14531944 | 0.92 | AURKB (0.40) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL14531920 | 0.91 | AURKB (0.40) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL14532319 | 0.86 | AURKB (0.48) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL13004595 | 0.85 | AURKB (0.61) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL14532311 | 0.82 | AURKB (0.48) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL14532308 | 0.82 | AURKB (0.48) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL14531946 | 0.81 | AURKB (0.49) | AURKBAURKAPLK4AURKCABL1 | |
| SCHEMBL14531915 | 0.80 | AURKA (0.47) | AURKBAURKAPLK4AURKCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056221-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-18 | — | — | WO | disclosed |