Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | INSR | P06213 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6096008 | 0.89 | IGF1R (0.81) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL14535564 | 0.86 | IGF1R (0.67) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL14535557 | 0.82 | IGF1R (0.57) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL5136755 | 0.81 | IGF1R (0.79) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL5136895 | 0.81 | IGF1R (0.81) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL14535405 | 0.79 | IGF1R (0.66) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL6096317 | 0.79 | IGF1R (0.81) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL3998266 | 0.79 | IGF1R (0.78) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL5072446 | 0.79 | IGF1R (1.00) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL5147090 | 0.78 | IGF1R (1.00) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223757-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-29 | — | — | US | disclosed |