Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.49 |
| ▸ | BRD4 | O60885 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | JAK3 | P52333 | 13/20 | 0.47 |
| ▸ | SYK | P43405 | 5/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | WEE1 | P30291 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | PAK4 | O96013 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270658 | 0.90 | JAK1 (0.51) | JAK1BRD4HDAC1JAK2JAK3 | |
| SCHEMBL12111065 | 0.85 | JAK3 (0.49) | JAK1BRD4HDAC1JAK2JAK3 | |
| SCHEMBL270505 | 0.83 | JAK1 (0.50) | JAK1BRD4HDAC1JAK2JAK3 | |
| SCHEMBL17915957 | 0.81 | BRD4 (0.51) | JAK1BRD4JAK2JAK3SYK | |
| SCHEMBL306757 | 0.81 | JAK1 (0.45) | JAK1BRD4HDAC1JAK2JAK3 | |
| SCHEMBL13494388 | 0.81 | BRD4 (0.57) | JAK1BRD4HDAC1JAK2JAK3 | |
| SCHEMBL12321387 | 0.80 | JAK3 (0.60) | JAK1BRD4HDAC1JAK2JAK3 | |
| SCHEMBL13868406 | 0.79 | EGFR (0.53) | BRD4JAK2JAK3SYKEGFR | |
| SCHEMBL12111172 | 0.78 | EGFR (0.60) | JAK1BRD4HDAC1JAK2JAK3 | |
| SCHEMBL301475 | 0.78 | BRD4 (0.55) | BRD4HDAC1JAK2JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053452-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2007-05-10 | — | — | WO | disclosed |