Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 7/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426780 | 0.92 | FYN (0.47) | FYNAURKAAURKBTTKABCG2 | |
| SCHEMBL8241264 | 0.92 | FYN (0.46) | FYNAURKAAURKBTTKABCG2 | |
| SCHEMBL14538580 | 0.89 | FYN (0.43) | FYNAURKAAURKBTTKPTK6 | |
| SCHEMBL8239650 | 0.87 | TTK (0.44) | FYNAURKATTKEGFRBRAF | |
| SCHEMBL8241257 | 0.86 | BRD4 (0.43) | FYNAURKATTKEGFRPTK6 | |
| SCHEMBL14537088 | 0.85 | FYN (0.45) | FYNAURKAAURKBTTKABCG2 | |
| SCHEMBL12473556 | 0.85 | FYN (0.47) | FYNAURKAAURKBTTKABCG2 | |
| SCHEMBL8240815 | 0.82 | FYN (0.44) | FYNAURKAAURKBTTKABCG2 | |
| SCHEMBL8241294 | 0.82 | FYN (0.44) | FYNAURKAAURKBTTKABCG2 | |
| SCHEMBL8239882 | 0.79 | AURKA (0.63) | FYNAURKAAURKBTTKABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |