Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 16/20 | 0.40 |
| ▸ | AURKA | O14965 | 12/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536800 | 0.93 | AURKB (0.39) | TTKAURKBAURKAPTK6CHEK1 | |
| SCHEMBL14507633 | 0.90 | TTK (0.40) | TTKAURKBAURKAPTK6CHEK1 | |
| SCHEMBL14507631 | 0.89 | TTK (0.39) | TTKAURKBAURKAPTK6LCK | |
| SCHEMBL14507635 | 0.89 | PTK6 (0.41) | TTKAURKBAURKAPTK6 | |
| SCHEMBL14507639 | 0.89 | TTK (0.40) | TTKAURKBAURKAPTK6FGFR1 | |
| SCHEMBL14508090 | 0.88 | TTK (0.40) | TTKAURKBAURKAPTK6FGFR1 | |
| SCHEMBL14507603 | 0.86 | AURKB (0.39) | TTKAURKBAURKAPTK6 | |
| SCHEMBL14507581 | 0.85 | AURKB (0.53) | AURKBAURKACHEK1RPS6KA3 | |
| SCHEMBL14507582 | 0.84 | AURKB (0.43) | AURKBAURKACHEK1LCKFLT3 | |
| SCHEMBL14507591 | 0.84 | ANPEP (0.41) | TTKAURKBAURKAPTK6FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |