Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 13/20 | 0.69 |
| ▸ | AURKA | O14965 | 10/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8239888 | 0.90 | AURKA (0.70) | AURKBAURKACHEK1LCKCDK2 | |
| SCHEMBL12404449 | 0.84 | AURKB (0.64) | AURKBAURKACHEK1LCKPTK6 | |
| SCHEMBL8241796 | 0.81 | AURKB (1.00) | AURKBAURKACHEK1LCKPTK6 | |
| SCHEMBL8246082 | 0.81 | CHEK1 (0.64) | AURKBAURKACHEK1LCKCDK2 | |
| SCHEMBL14529991 | 0.81 | CHEK1 (0.64) | AURKBAURKACHEK1LCKCDK2 | |
| SCHEMBL14507772 | 0.79 | AURKA (0.66) | AURKBAURKACHEK1LCKPTK6 | |
| SCHEMBL14537036 | 0.79 | AURKB (0.60) | AURKBAURKACHEK1LCKPTK6 | |
| SCHEMBL13259841 | 0.77 | AURKA (0.50) | AURKBAURKACHEK1CDK2IRAK4 | |
| SCHEMBL8241241 | 0.77 | AURKA (0.90) | AURKBAURKACHEK1LCKCDK2 | |
| SCHEMBL12404563 | 0.76 | AURKB (0.61) | AURKBAURKACHEK1CDK2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |