Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12404631 | 0.82 | AURKB (0.45) | AURKAAURKBFYNCHEK1CCNA2 | |
| SCHEMBL12404629 | 0.82 | AURKB (0.52) | AURKAAURKBCHEK1PTK6 | |
| SCHEMBL14536799 | 0.81 | AURKB (0.49) | AURKAAURKBCHEK1CCNA2CDK2 | |
| SCHEMBL14537036 | 0.81 | AURKB (0.60) | AURKAAURKBCHEK1PTK6IRAK4 | |
| SCHEMBL8247338 | 0.81 | AURKA (0.73) | AURKAAURKBCHEK1CDK2IRAK4 | |
| SCHEMBL14536793 | 0.80 | CHEK1 (0.39) | AURKAAURKBFYNCHEK1CCNA2 | |
| SCHEMBL14507675 | 0.80 | AURKB (0.48) | AURKAAURKBCHEK1CCNA2CDK2 | |
| SCHEMBL14507672 | 0.80 | AURKB (0.46) | AURKAAURKBFYNCHEK1CCNA2 | |
| SCHEMBL12404638 | 0.79 | AURKB (0.49) | AURKAAURKBCHEK1PTK6 | |
| SCHEMBL12404627 | 0.79 | AURKB (0.58) | AURKAAURKBCHEK1PTK6IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |