Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.60 |
| ▸ | AURKA | O14965 | 15/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 14/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13155374 | 1.00 | CHEK1 (0.60) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL13955001 | 0.88 | LCK (0.72) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL14538375 | 0.86 | CHEK1 (0.49) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL8239888 | 0.82 | AURKA (0.70) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL14507498 | 0.82 | CHEK1 (0.60) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL8246082 | 0.81 | CHEK1 (0.64) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL14529991 | 0.81 | CHEK1 (0.64) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL13899597 | 0.80 | AURKA (0.43) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL12404571 | 0.79 | CHEK1 (0.59) | CHEK1AURKAAURKBLCKCDK2 | |
| SCHEMBL13155408 | 0.79 | LCK (0.79) | CHEK1AURKAAURKBLCKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |