Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 5/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240324 | 0.88 | AURKA (0.66) | AURKAAURKBCHEK1TTKPTK6 | |
| SCHEMBL8239904 | 0.80 | AURKA (0.61) | AURKAAURKBCHEK1TTKFYN | |
| SCHEMBL8241208 | 0.79 | AURKA (0.55) | AURKAAURKBCHEK1TTKPTK6 | |
| SCHEMBL8241252 | 0.79 | AURKA (1.00) | AURKAAURKBCHEK1 | |
| SCHEMBL8247201 | 0.79 | AURKA (0.68) | AURKAAURKBCHEK1TTKPTK6 | |
| SCHEMBL12473190 | 0.77 | AURKA (0.62) | AURKAAURKBCHEK1TTKPTK6 | |
| SCHEMBL8239744 | 0.77 | AURKA (0.64) | AURKAAURKBCHEK1TTKFYN | |
| SCHEMBL8240371 | 0.77 | AURKA (0.70) | AURKAAURKBCHEK1TTKFYN | |
| SCHEMBL8246055 | 0.77 | AURKA (0.64) | AURKAAURKBCHEK1TTKPTK6 | |
| SCHEMBL14538573 | 0.76 | AURKA (0.56) | AURKAAURKBCHEK1TTKPTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |