Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.47 |
| ▸ | AXL | P30530 | 9/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246259 | 0.81 | AURKA (0.55) | AURKAAURKBAXLTTK | |
| SCHEMBL8246264 | 0.79 | AURKA (0.54) | AURKAAURKBAXL | |
| SCHEMBL8241606 | 0.73 | AURKA (0.58) | AURKAAURKBPTK6MAPKAPK5 | |
| SCHEMBL8240162 | 0.73 | AURKA (0.62) | AURKAAURKBAXLTTKPTK6 | |
| SCHEMBL8240330 | 0.72 | AURKA (0.63) | AURKAAURKBTTKPTK6MAPKAPK5 | |
| SCHEMBL8426888 | 0.72 | AURKA (0.58) | AURKAAURKBAXLPTK6MAPKAPK5 | |
| SCHEMBL8240367 | 0.71 | AURKA (0.60) | AURKAAURKBTTKPTK6MAPKAPK5 | |
| SCHEMBL14530382 | 0.71 | AURKA (0.71) | AURKAAURKBTTKPTK6MAPKAPK5 | |
| SCHEMBL8246792 | 0.71 | AURKA (0.62) | AURKAAURKBTTKPTK6MAPKAPK5 | |
| SCHEMBL8246048 | 0.71 | AURKA (0.66) | AURKAAURKBTTKPTK6MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |