Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | WNT1 | P04628 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241171 | 0.88 | AURKA (0.59) | AURKAAURKBACVR1TTKPTK6 | |
| SCHEMBL8246328 | 0.84 | AURKA (0.56) | AURKAAURKBACVR1TTKPTK6 | |
| SCHEMBL8240971 | 0.75 | AURKA (0.66) | AURKAAURKBTTKPTK6DYRK1A | |
| SCHEMBL8249789 | 0.74 | AURKA (0.58) | AURKAAURKBTTKAXLTYRO3 | |
| SCHEMBL8241160 | 0.74 | AURKA (0.49) | AURKAAURKBTTK | |
| SCHEMBL13154928 | 0.73 | AURKA (0.57) | AURKAAURKBGSK3BDYRK1AFLT3 | |
| SCHEMBL8239892 | 0.73 | AURKA (0.56) | AURKAAURKBTTKPTK6GSK3B | |
| SCHEMBL8241321 | 0.73 | AURKA (0.56) | AURKAAURKBTTKPTK6GSK3B | |
| SCHEMBL8239849 | 0.73 | AURKA (0.54) | AURKAAURKBTTKPTK6FYN | |
| SCHEMBL8240704 | 0.72 | AURKA (0.47) | AURKAAURKBTTKPTK6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |