Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.67 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925611 | 0.89 | NTRK1 (0.71) | NTRK1NTRK2RETKDR | |
| SCHEMBL1924948 | 0.89 | NTRK1 (0.69) | NTRK1NTRK2RETKDRKCNH2 | |
| SCHEMBL3980576 | 0.89 | NTRK1 (0.69) | NTRK1NTRK2RETKDR | |
| SCHEMBL1924266 | 0.88 | NTRK1 (0.67) | NTRK1NTRK2RETKDRKCNH2 | |
| SCHEMBL1924685 | 0.88 | NTRK1 (0.62) | NTRK1NTRK2RETKDRKCNH2 | |
| SCHEMBL1925029 | 0.87 | NTRK1 (0.66) | NTRK1NTRK2KCNH2 | |
| SCHEMBL1924896 | 0.86 | NTRK2 (0.69) | NTRK1NTRK2RETKDRKCNH2 | |
| SCHEMBL1924225 | 0.86 | NTRK1 (0.67) | NTRK1NTRK2KCNH2NTRK3ACVRL1 | |
| SCHEMBL1925123 | 0.85 | NTRK2 (0.81) | NTRK1NTRK2RETKDRKCNH2 | |
| SCHEMBL1924558 | 0.85 | NTRK1 (0.61) | NTRK1NTRK2RETKDRNTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007061882-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |