Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | NMT1 | P30419 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | NMT2 | O60551 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537568 | 0.89 | MAPT (0.72) | MAPTNPSR1KDM4EGAAATM | |
| SCHEMBL14537564 | 0.86 | MAPT (0.79) | MAPTNPSR1KDM4EGAAATM | |
| SCHEMBL14537571 | 0.84 | MAPT (0.76) | MAPTNPSR1KDM4EGAAATM | |
| SCHEMBL14537566 | 0.84 | MAPT (0.69) | MAPTNPSR1KDM4EGAAATM | |
| SCHEMBL14537569 | 0.81 | MAPT (0.70) | MAPTNPSR1KDM4EGAAATM | |
| SCHEMBL8884456 | 0.80 | MAPT (0.64) | MAPTNPSR1KDM4EGAAATM | |
| SCHEMBL1178069 | 0.80 | KMT2A (0.58) | MAPTKDM4EGAAALDH1A1CYP3A4 | |
| SCHEMBL1178859 | 0.79 | MEN1 (0.55) | MAPTKDM4EGAAALDH1A1CYP3A4 | |
| SCHEMBL14537586 | 0.79 | CYP3A4 (0.50) | MAPTKDM4EALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL23575505 | 0.78 | MAPT (0.68) | MAPTKDM4EGAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349867-B2 | Quinoline compounds, intermediates, preparation methods and uses thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2013-01-08 | — | — | US | disclosed |