Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 6/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604183 | 0.93 | GSK3A (0.52) | CCR3ACKR3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4604374 | 0.90 | CCR3 (0.50) | CCR3ACKR3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14538507 | 0.88 | LCK (0.47) | CCR3ACKR3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4606143 | 0.80 | GSK3A (0.51) | CCR3SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL4604262 | 0.78 | LCK (0.48) | SMN1; SMN2NPC1RAB9AGSK3AGSK3B | |
| SCHEMBL4891368 | 0.74 | CCR3 (0.53) | CCR3ACKR3MEN1KMT2ARAB9A | |
| SCHEMBL4900572 | 0.71 | CCR3 (0.62) | CCR3ACKR3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL27719387 | 0.70 | TMEM97 (0.60) | CCR3ACKR3MEN1KMT2ARAB9A | |
| SCHEMBL4605023 | 0.69 | CCR3 (0.57) | CCR3ACKR3KMT2ATMEM97SIGMAR1 | |
| SCHEMBL4603538 | 0.69 | CCR3 (0.60) | CCR3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007048771-A1 | ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | NOVARTIS AG (CH) | 2007-05-03 | — | — | WO | disclosed |