Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 12/20 | 0.59 |
| ▸ | AURKA | O14965 | 11/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536769 | 0.90 | AURKB (0.62) | AURKBAURKACHEK1PTK6TTK | |
| SCHEMBL14507418 | 0.90 | AURKA (0.56) | AURKBAURKACHEK1PTK6TTK | |
| SCHEMBL14533869 | 0.88 | AURKA (0.58) | AURKBAURKACHEK1PTK6TTK | |
| SCHEMBL12404532 | 0.88 | AURKA (0.64) | AURKBAURKACHEK1PTK6TTK | |
| SCHEMBL14507416 | 0.88 | AURKA (0.64) | AURKBAURKACHEK1PTK6TTK | |
| SCHEMBL12404526 | 0.87 | AURKB (0.58) | AURKBAURKACHEK1PTK6TTK | |
| SCHEMBL14507417 | 0.87 | AURKA (0.58) | AURKBAURKACHEK1TTK | |
| SCHEMBL12404535 | 0.86 | AURKA (0.63) | AURKBAURKACHEK1PTK6TTK | |
| SCHEMBL12404525 | 0.86 | AURKA (0.65) | AURKBAURKACHEK1PTK6TTK | |
| SCHEMBL12404523 | 0.85 | AURKA (0.57) | AURKBAURKACHEK1PTK6TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |