Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 19/20 | 0.59 |
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
| ▸ | LCK | P06239 | 3/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473048 | 0.85 | LCK (0.74) | AURKBAURKALCKCHEK1RPS6KA3 | |
| SCHEMBL13155517 | 0.84 | AURKB (0.74) | AURKBAURKALCKCHEK1RPS6KA3 | |
| SCHEMBL13155502 | 0.83 | AURKB (0.74) | AURKBAURKALCKCHEK1RPS6KA3 | |
| SCHEMBL13155507 | 0.83 | AURKB (0.74) | AURKBAURKALCKCHEK1RPS6KA3 | |
| SCHEMBL13155516 | 0.83 | AURKB (0.74) | AURKBAURKALCKCHEK1RPS6KA3 | |
| SCHEMBL13954842 | 0.83 | AURKB (0.56) | AURKBAURKALCKCHEK1RPS6KA3 | |
| SCHEMBL12404520 | 0.83 | AURKB (0.76) | AURKBAURKACHEK1 | |
| SCHEMBL13155508 | 0.82 | AURKB (0.64) | AURKBAURKALCKCHEK1RPS6KA3 | |
| SCHEMBL12588164 | 0.82 | AURKB (0.58) | AURKBAURKALCKCHEK1RPS6KA3 | |
| SCHEMBL13955030 | 0.82 | AURKB (0.57) | AURKBAURKALCKCHEK1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |