Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.70 |
| ▸ | PTK6 | Q13882 | 6/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 13/20 | 0.41 |
| ▸ | AURKA | O14965 | 11/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12471141 | 0.93 | CHEK1 (0.69) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL12471034 | 0.92 | CHEK1 (0.68) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL14538629 | 0.91 | CHEK1 (0.66) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL12473573 | 0.91 | CHEK1 (0.66) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL12471674 | 0.91 | CHEK1 (0.66) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL14507696 | 0.89 | CHEK1 (0.77) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL12473566 | 0.86 | CHEK1 (0.70) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL14537065 | 0.85 | CHEK1 (0.68) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL12471221 | 0.85 | CHEK1 (0.58) | CHEK1PTK6AURKBAURKALCK | |
| SCHEMBL12473567 | 0.85 | CHEK1 (0.77) | CHEK1PTK6AURKBAURKALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |