Sugi Predict

Sugi Predict / Compounds / SCHEMBL14540658

SCHEMBL14540658

SCHEMBL14540658

CCCNC(=O)Nc1ccc(Oc2ncnc3[nH]c(-c4ccc(OCc5ccccc5)cc4)cc23)cc1Cl

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 8/20 0.57
▸ FLT1 P17948 4/20 0.57
▸ FLT4 P35916 4/20 0.57
▸ KIT P10721 2/20 0.57
▸ PDGFRA P16234 2/20 0.57
▸ PRMT5 O14744 12/20 0.50
▸ CSF1R P07333 1/20 0.44
▸ RET P07949 1/20 0.44
▸ FLT3 P36888 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1893095 0.86 PRMT5 (0.51) KDRFLT1FLT4PRMT5
SCHEMBL5205647 0.80 KDR (0.86) KDRFLT1FLT4KITPDGFRA
SCHEMBL5205807 0.80 KDR (0.86) KDRFLT1FLT4KITPDGFRA
SCHEMBL1898781 0.75 KDR (0.55) KDRFLT1FLT4KITPDGFRA
SCHEMBL1890092 0.74 KDR (0.51) KDRFLT1FLT4KITPDGFRA
SCHEMBL12411683 0.73 KDR (0.50) KDRFLT1FLT4KITPDGFRA
SCHEMBL1894377 0.73 KDR (0.49) KDRFLT1FLT4KITPDGFRA
SCHEMBL1893909 0.73 KDR (0.48) KDRFLT1FLT4KITPDGFRA
SCHEMBL1893911 0.73 KDR (0.48) KDRFLT1FLT4KITPDGFRA
SCHEMBL1892870 0.73 FLT3 (0.59) KDRFLT1FLT4KITPRMT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1777218-A1 Process for the preparation of 4-phenoxy quinoline derivatives Eisai R&D Management Co., Ltd. (JP) 2007-04-25 — — EP disclosed